A transmitter includes a first mixer to generate a first output signal by up-converting a first baseband signal having a first DC offset component. A second mixer generates a second output signal by up-converting a second baseband signal having a second DC offset component. The second output signal is subtracted from the first output signal to generate a transmitter output signal. The transmitter output signal includes a local oscillator (LO) leakage signal caused by the first and/or second DC offset components. A third mixer produces a third output signal by up-converting the first DC offset component. A fourth mixer produces a fourth output signal by up-converting the second DC offset component. The fourth output signal is subtracted from the third output signal to generate a LO leakage cancellation signal. The LO leakage cancellation signal is subtracted from the transmitter output signal, thereby reducing a power of the LO leakage signal.