Methods and devices for treating obesity are provided. The consumption of calorie dense, lipid rich, or fatty foods is discouraged through the modulation of a subjects gallbladder function or output. Disclosed are devices and methods for delivering devices within the gallbladder and associated ducts and vasculature; other methods involve implanting devices on or around the gallbladder and associated ducts and vasculature. Further treatments involve the use of energy, surgery, or chemicals to alter the function of the gallbladder and biliary system.