A low noise digital radiography image capture system employs a two-dimensional array of pixel sites in the image capture panel with each site having an analog-to-digital converter to digitize analog charge values produced by imaging radiation directly into corresponding digital data at the site prior to read-out to subsequent digital data processing electronics thereby avoiding noise and crosstalk problems associated with high frequency read-out of analog information. Fill factor problems caused by inclusion of integrated circuitry on the pixel site are minimized by inclusion of the A/D counter on the opposite side of the substrate support for the pixel site.