Polymeric materials are used to make a pliable, non-toxic, injectable
porous template for vascular ingrowth. The pore size, usually between
approximately 100 and 300 microns, allows vascular and connective tissue
ingrowth throughout approximately 10 to 90% of the matrix following
implantation, and the injection of cells uniformly throughout the
implanted matrix without damage to the cells or patient. The introduced
cells attach to the connective tissue within the matrix and are fed by
the blood vessels. The preferred material for forming the matrix or
support structure is a biocompatible synthetic polymer which degrades in
a controlled manner by hydrolysis into harmless metabolites, for example,
polyglycolic acid, polylactic acid, polyorthoester, polyanhydride, or
copolymers thereof. The rate of tissue ingrowth increases as the porosity
and/or the pore size of the implanted devices increases. The time
required for the tissue to fill the device depends on the polymer
crystallinity and is less for amorphous polymers versus semicrystalline
polymers. The vascularity of the advancing tissue is consistent with time
and independent of the biomaterial composition and morphology.