A system and a method for determining whether an operator of a vehicle has an impaired cognitive state are provided. The method includes determining an intoxication indication value indicative of whether the operator is intoxicated, utilizing a controller. The method further includes determining a drowsiness indication value indicative of whether the operator is drowsy, utilizing the controller. The method further includes determining a fatigue indication value indicative of whether the operator is fatigued, utilizing the controller. The method further includes determining a cognitively impaired indication value based on at least one of the intoxication indication value, the drowsiness indication value, and the fatigue indication value. The method further includes generating a signal indicating that the operator is cognitively impaired when the cognitively impaired indication value is greater than a threshold cognitively impaired indication value, utilizing the controller.