Method and systems for treating a vulnerable plaque associated with a blood vessel of a patient are disclosed. The method includes positioning an endoluminal device within a lumen of the blood vessel. An expandable member of the endoluminal device is expanded adjacent a wall of the blood vessel. A blood vessel coating substance is administered from the expanded expandable member. The administered blood vessel coating substance adheres to the wall of the blood vessel. A first system includes an endoluminal device including at least one aperture formed therein. An expandable member is operably attached to the endoluminal device. The expandable member comprises an outer surface including at least one groove disposed thereon. The expandable member is expanded within the blood vessel and a blood vessel coating substance is administered through the aperture and onto the expandable member outer surface. A second system includes means for positioning an endoluminal device within a lumen of the blood vessel and means for expanding an expandable member of the endoluminal device adjacent a wall of the blood vessel. The second system further includes means for administering a blood vessel coating substance from the expanded expandable member and means for adhering the administered blood vessel coating substance to the wall of the blood vessel.