The specification discloses modified Clostridial toxins comprising a PAR
ligand domain, a Clostridial toxin enzymatic domain, a Clostridial toxin
translocation domain and a Clostridial toxin binding domain;
polynucleotide molecules encoding modified Clostridial toxins comprising
a PAR ligand domain, a Clostridial toxin enzymatic domain, a Clostridial
toxin translocation domain and a Clostridial toxin binding domain; and
method of producing modified Clostridial toxins comprising a PAR ligand
domain, a Clostridial toxin enzymatic domain, a Clostridial toxin
translocation domain and a Clostridial toxin binding domain.