The invention is directed towards a process for implanting a cartilage
graft into a cartilage defect and sealing the implanted cartilage graft
with recipient tissue by creating a first bore down to the bone portion
of the cartilage defect, creating a second shaped bore that is concentric
to and on top of the first bore to match the shape and size of the
cartilage graft, treating the first bore and the second shaped bore at
the defect site with a bonding agent, treating the circumferential area
of the cartilage graft with a bonding agent, inserting the cartilage
graft into the defect site and wherein the superficial surface of the
cartilage graft is at the same height as the surrounding cartilage
surface. The first and second bonding agents may be activated by applying
a stimulation agent to induce sealing, integration, and restoration of
the hydrodynamic environments of the recipient tissue. The invention is
also directed towards a process for repairing a cartilage defect and
implanting a cartilage graft into a human or animal by crafting a
cartilage matrix into individual grafts, cleaning and disinfecting the
cartilage graft, applying a pretreatment solution to the cartilage graft,
removing cellular debris using an extracting solution to produce a
devitalized cartilage graft, implanting the cartilage graft into the
cartilage defect with or without an insertion device, and sealing the
implanted cartilage graft with recipient tissue. The devitalized
cartilage graft is optionally recellularized in vitro, in vivo, or in
situ with viable cells to render the tissue vital before or after the
implantation. The devitalized cartilage graft is also optionally stored
between the removing cellular debris and the recellularizing steps. The
invention is further directed toward a repaired cartilage defect.