Medicine delivery interface for delivery of therapeutic aerosols or gases, including at least one hollow body having at least one nasal aperture defined therein at least one nasal insert tube associated with each nasal aperture of the hollow body is capable of being inserted into a nostril. The interface also may include at least one exhaust aperture having at least one exhaust valve configured to exhaust exhaled gases and configured to block inflow of air through the exhaust aperture and at least one intake aperture.