Methods, apparatus, systems and the like for treating acne vulgaris that improves treatment effectiveness and/or reduces bothersome side effects associated with the ingredients used. The present Methods, apparatus, systems, etc., also provide topical compositions of benzoyl peroxide and/or other anti-acne agents that are useful for treating acne vulgaris and may be used simultaneously or sequentially in a user-adjustable ratio of two or more such compositions, or other compositions as desired such as cleansers or lotions.