A nasal irrigation solution comprising is disclosed comprising water and hydrastine extracted from one or more plants. Another solution comprises water and berberine extracted from one or more plants. These solutions are provided from an extract of goldenseal plant. Solutions are also disclosed having canadine, canadaline, and hydrastidine, all extracted from the goldenseal plant. More general solutions are disclosed including alkaloids extracted from one or more plants. The alkaloids are selected from one or more of the group consisting of: berberine, oxyberberine, berbamine, palmatine, magnoflorine, phellodendrine, jateorrhizine, candicine, menisperine, coptisine, worenine, columbamine, epiberberine, hydrastine, canadine, canadaline, hydrastidine, oxycyanthine, berberrubine, and isotetrandine. Alkaloids are provided from plant from the group consisting of: Oregon grape root, yellow root, phellodendron bark, coptis rhizome, barberry root, and Indian barberry root bark. Other constituents may include extract of grapefruit seed, vegetable glycerine, salt, and water soluble zinc. A method for using these solutions is disclosed which includes flowing the solution through desired portions of nasal cavities.