A system and method are disclosed for very accurately determining a value of a substrate doping density in a metal oxide semiconductor device. A plurality of values of threshold voltage of a device under test are measured using a plurality of different values of source to substrate bias voltage. Then a linear relationship is determined between the plurality of values of threshold voltage and a plurality of different values of an expression that is a function of the source to substrate bias voltage and a function of a surface potential of the device. A very accurate value of the substrate doping density is reiteratively calculated from the linear relationship without assuming that the surface potential of the device has a constant value.