Novels immuno-interactive fragments of the (alpha)C portion of a mammalian
inhibin alpha subunit are disclosed, together with their variants and
derivatives for producing antigen-binding molecules that are interactive
with said (alpha)C portion, which are chemically well defined and which
can be produced in commercially significant quantities. The
antigen-binding molecules of the invention can be used for the detection
of a mammalian inhibin and for the treatment and/or prevention of
conditions associated with aberrant levels of a mammalian inhibin.