Drop dispensers are provided which comprise a first portion, the first portion including a dispensing tip, the dispensing tip including an annular groove around an outer part of the dispensing tip, and a nozzle having a through-opening; and a second portion having a closed end, wherein the first portion is angularly disposed from the second portion and the dispensing tip is distal from the closed end. Exemplary drop dispensers also provide for a removable cannula tip for conveying liquids contained within the drop dispenser to a precise location in the eye, ear, nose, or mouth. Removable cannula tips are provided comprising an aperture for dispensing liquids, and an elastomeric annular ring capable of seating in the annular groove of the dispensing tip, wherein the aperture is distal to the elastomeric annular ring. The drop dispensers described are particularly well suited for the dispensing of ophthalmic solutions.