The present invention relates to an ozone treatment apparatus using ozone gas, in which the ozone gas is directly injected to a lesion of the human body by utilizing the sterilizing power caused by oxidation of ozone gas, so that the lesion can be sterilized and stanched to relieve the pain in the lesion, thereby maximizing therapeutic effect by the ozone irrespective of the shape of bodily regions having the lesion and the kind of lesion, and so that the treatment using ozone gas can be readily conducted, thereby improving convenience in use as well as significantly reducing the cost and time spent for the treatment.