A method and system of modifying instructions forming a loop is provided. A method of modifying instructions forming a loop includes modifying instructions forming a loop including: determining static and dynamic characteristics for the instructions; selecting a modification factor for the instructions based on a number of separate equivalent sections forming a cache in a processor which is processing the instructions; and modifying the instructions to interleave the instructions in the loop according to the modification factor and the static and dynamic characteristics when the instructions satisfy a modification criteria based on the static and dynamic characteristics.