A system for treating obesity, comprises an injectable compound for
intramuscular administration in a pyloric sphincter, the injectable
compound including a plurality of microspheres and a fluid carrier in
which the microspheres are suspended. The system further comprises an
injection device having flexibility sufficient to pass through a working
channel of an endoscope into the stomach to an injection location
adjacent to the pyloric sphincter, the injection device including a
tissue piercing tip and a lumen through which the injectable compound may
be delivered.