The present invention is directed to an isolated peptide that functionally
mimics a binding site for a monoclonal antibody, the monoclonal antibody
recognizing an epitope within the human platelet glycoprotein Ib/IX
complex. This peptide is called a mimotope. The invention also provides
an isolated molecule capable of binding to the peptide, or the mimotope,
which molecule can be an antibody, a second peptide, a carbohydrate, a
DNA molecule, an RNA molecule, or other naturally or chemically
synthesized molecules. This isolated molecule is called an anti-mimotope.
Mimotopes mimicking the binding site for monoclonal antibody C-34 and
SZ-2, as well as anti-mimotopes to the C-34 mimotopes, are specifically
provided.