This invention provides aryl and heteroaryl compounds, methods of their
preparation, pharmaceutical compositions comprising the compounds, and
their use in treating human or animal disorders. The compounds of the
invention may be antagonists, or partial antagonist of factor IX and/or
factor XI and thus, may be useful for inhibiting the intrinsic pathway of
blood coagulation. The compounds may be useful in a variety of
applications including the management, treatment and/or control of
diseases caused in part by the intrinsic clotting pathway.