Systems and methods for course and fine synchronization are provided. In one embodiment, a method comprises establishing communication between a first remote of a plurality of remote units and a host, the plurality of remote units coupled to the host in a multipoint-to-point configuration; transmitting up to a plurality of tones from the first remote, the tones modulated with upstream information using orthogonal frequency division multiplexing (OFDM); making a first adjustment in a manner in which transmissions are transmitted from the first remote on at least one of the tones, the first adjustment varying the alignment of the transmissions received at the host; and making a second adjustment in the manner in which transmissions are transmitted from the first remote on the at least one of the tones, the second adjustment varying the alignment of the transmissions received at the host, wherein the second adjustment is finer the first adjustment.