Multiple strains and species of Campylobacter share a common glycan moiety
which is present in a plurality of surface-exposed glycoproteins. This
glycan has the formula: GalNAc-a1,
4-GalNAc-a1,4-[Glc-.beta.1,3]GalNAc-a1,4-GalNAc-a1,4-GalNAc-a1,3-Bac,
wherein Bac is 2, 4-diacetamido-2,4,6-trideoxy-D-glucopyranose. This
glycan and immunologically active fragments of it have use as vaccines
against campylobacter infection in humans and animals. As well,
antibodies which specifically bind these compounds may be provided. Such
antibodies and vaccines may be used to prevent or neutralize
campylobacter infections in livestock thereby preventing this pathogen
from entering the human food chain. The glycan may be linked to one or
more amino acids to form a glycopeptide. As well, a method for
determining the glycan structure of an intact glycoprotein consists of
subjecting a sample to high resolution magic angle spinning nuclear
magnetic resonance (HR-MAS-NMR) spectroscopy.