The present invention relates to compounds having the formula,
##STR00001## and pharmaceutically-acceptable salts, prodrugs, solvates,
isomers, and/or hydrates thereof, wherein Q is an optionally-substituted
phenyl, pyridyl, pyridazinyl, pyrimidinyl, or pyrazinyl ring; R.sub.2 is
alkyl or an amino group as defined herein; and Z is
optionally-substituted oxadiazolyl or --C(.dbd.O)NR.sub.6, wherein
R.sub.6 is lower alkyl or cyclopropyl. The compounds are surprisingly
advantageous in preparing pharmaceutical compositions for treating p38
kinase related conditions and/or in methods of treating conditions
associated with the activity of p38 kinase in a patient.