A method for reducing noise associated with an audio signal received through a microphone sensor array is provided. The method initiates with enhancing a target signal component of the audio signal through a first filter. Simultaneously, the target signal component is blocked by a second filter. Then, the output of the first filter and the output of the second filter are combined in a manner to reduce noise without distorting the target signal. Next, an acoustic set-up associated with the audio signal is periodically monitored. Then, a value of the first filter and a value of the second filter are both calibrated based upon the acoustic set-up. A system capable of isolating a target audio signal from multiple noise sources, a video game controller, and an integrated circuit configured to isolate a target audio signal are included.