The object of the present invention is to provide a compound having an ACC
inhibitory action, which is useful for the prophylaxis or treatment of
obesity, diabetes, hypertension, hyperlipidemia, cardiac failure,
diabetic complications, metabolic syndrome, sarcopenia and the like, and
has superior properties such as efficacy, duration of activity,
specificity, low toxicity and the like.
The present invention provides a compound represented by the following
formula
##STR00001##
whereinring M is a 5- or 6-membered aromatic ring;W is C or N;K is an
optionally substituted methylene group or an optionally substituted imino
group;R is a hydrogen atom, an optionally substituted hydrocarbon group,
an optionally substituted hydroxy group or an optionally substituted
heterocyclic group;T and U are independently a hydrogen atom or a
substituent or, T and U form, together with ring M, an optionally
substituted bicyclic ring;D and G are independently a carbonyl group or a
sulfonyl group; ring P is an optionally substituted piperidine or an
optionally substituted piperazine;B is CH or N;ring Q is an optionally
substituted monocyclic ring;A is C, CH or N; andJ is an optionally
substituted hydrocarbon group, an optionally substituted heterocyclic
group or an optionally substituted amino group,provided that when the W
moiety of ring M is .dbd.N-- or --N.dbd., then U should be absent,or a
salt thereof.