A Canis sphingosine-1-phosphate (S1P) receptor isoform 1 (cS1P.sub.1), the nucleic acid encoding the cS1P.sub.1 receptor, and methods for using the cS1P.sub.1 receptor and the nucleic acid encoding the cS1P.sub.1 receptor in assays for identifying analytes which modulate activity of the cS1P.sub.1 receptor.

 
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