Methods for concomitant administration of colchicine together with one or
more macrolide antibiotics, e.g., clarithromycin or erythromycin, are
disclosed. Such methods reduce the dangers commonly associated with such
concomitant administration and provide additional benefits. Methods of
notifying health care practitioners and patients regarding appropriate
dosing for co-administration of colchicine together with macrolide
antibiotics are also provided.