The present invention relates to a direction guide vibration system of a vehicle operating with a navigation and control method thereof, which applies vibration to a driver's seat on which a driver sits at the spot where a left turn or a right turn and a U turn are expected, on a path to move to a driver's intended destination, informs a driver thereof in advance for people and the hearing impaired using a navigation and informs the driver thereof before an enforcement area in which an over-speed camera is installed, thereby securing a safe driving of a vehicle.