A method and receiver are disclosed for mitigating or substantially canceling signal interference between signals detected at the receiver. Once a presumed interfering signal(s) is acquired, parameters are determined that allow the interferer(s) to be modeled. The phase invariance of the process eliminates the need to acquire the interferer's phase. An orthogonal projection (for projecting onto a detection subspace which is orthogonal to a subspace spanned by the interferer(s)) is applied to the composite of all signals (y) for thereby projecting y onto the detection subspace. The interference subspace is non-orthogonal to a representation of desired (but interfered) signal of the composite signals. With the receiver properly equipped to perform this projection operation, interfering signals, multipath, multipath-like, and structured jamming signals can be effectively diminished.