A security screening and support system for a venue having a plurality of access points includes a plurality of screening centers connected to a central control. The plurality or screening centers are arranged so as to be located in relation to the plurality of access points of the venue. The screening centers collect threat samples from subjects entering the venue, with the samples being screened for a threat signature, such as explosives. If a subject tests positive, an alert status is sent to the central control and a response, which is preferably randomized from a plurality of standard operating procedures, is enacted. The central control enables security personnel to view, monitor, respond and analyze threat situations.