Disclosed herein is a method, and system (1) for implementing same, to compensate for patient motion in series recordings in medical imaging, in which a plurality of images of an examination area of a patient (17) are recorded at time intervals with an imaging system (1) and related to each other. Before the start of the series recordings a 3D image data set is recorded by a 3D recording of the examination area, which establishes a reference system. A first spatial position of the examination area in the reference system is obtained by recording a first image of the series recordings and then registering it or by calculating it. Each further image of the series recordings is registered immediately after recording to obtain the current spatial position of the examination area. Differences in spatial position are compensated for at least approximately by changing geometric relationships of the imaging system (1).