The invention provides the use of a compound for the manufacture of a medicament for the treatment of pain, wherein the compound is a compound of the formula (0): ##STR00001## or a salt or tautomers or N-oxides or solvate thereof; wherein X is a group R.sup.1-A-NR.sup.4-- or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO.sub.2, C.dbd.O, NR.sup.g(C.dbd.O) or O(C.dbd.O) wherein R.sup.g is hydrogen or C.sub.1-4 hydrocarbyl optionally substituted by hydroxy or C.sub.1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R.sup.1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C.sub.1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen, hydroxy, C.sub.1-4 hydrocarbyloxy, amino, mono- or di-C.sub.1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO.sub.2; R.sup.2 is hydrogen; halogen; C.sub.1-4 alkoxy; or a C.sub.1-4 hydrocarbyl group optionally substituted by halogen, hydroxyl or C.sub.1-4 alkoxy (e.g. methoxy); R.sup.3 is selected from hydrogen and carbocyclic and heterocyclic groups having from 3 to 12 ring members; and R.sup.4 is hydrogen or a C.sub.1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C.sub.1-4 alkoxy. The invention also provides the use of the compounds of the formula (0) for the treatment of stroke and for the treatment of polycystic kidney disease.