The present invention provides substituted bicyclic heteroaryl compounds, including, for example, 4-pyrazolyl-N-arylpyrimidin-2-amines and 4-pyrazolyl-N-heteroarylpyrimidin-2-amines that modulate the activity of kinases and are useful in the treatment of diseases related to activity of kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

 
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> BRONCHIAL SMOOTH MUSCLE REMODELING INVOLVES CALCIUM-DEPENDENT ENHANCED MITOCHONDRIAL BIOGENESIS IN ASTHMA

> MEDICAL USE OF CYCLIN DEPENDENT KINASES INHIBITORS

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