Peptide of sequence TALRIRATYGEY (SEQ ID NO: 1) present on the gamma 2 chain of Laminin 5, a pharmaceutical composition containing the peptide and to the use of the composition for treating various skin alterations. More particularly, the treatment of the alterations includes reinforcing the derma-epidermal junction and the cell-matrix and/or cell-cell adherence of epidermis and in promoting the repair of a cutaneous surface.