mGluR5 antagonists are used for the treatment and prevention of disorders, including Fragile X, autism, mental retardation, schizophrenia and Down's Syndrome. The methods of the invention can be used to treat epilepsy and anxiety in a human having Fragile X syndrome, autism, mental retardation, schizophrenia and Down's Syndrome.

 
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> Azaindoles useful as inhibitors of JAK and other protein kinases

> Synthesis of epothilones, intermediates thereto and analogues thereof
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