This disclosure describes techniques that make use of a plurality of hardware elements that operate simultaneously to service synthesis parameters generated from one or more audio files, such as musical instrument digital interface (MIDI) files. In one example, a method comprises storing audio synthesis parameters generated for one or more audio files of an audio frame, processing a first audio synthesis parameter using a first audio processing element of a hardware unit to generate first audio information, processing a second audio synthesis parameter using a second audio processing element of the hardware unit to generate second audio information, and generating audio samples for the audio frame based at least in part on a combination of the first and second audio information.