Modified antibodies, or antigen-binding fragments thereof, to the
extracellular domain of human prostate specific membrane antigen (PSMA)
are provided. The modified anti-PSMA antibodies, or antigen-binding
fragments thereof, have been rendered less immunogenic compared to their
unmodified counterparts to a given species, e.g., a human. Pharmaceutical
compositions including the aforesaid antibodies, nucleic acids,
recombinant expression vectors and host cells for making such antibodies
and fragments are also disclosed. Methods of using the antibodies of the
invention to detect human PSMA, or to ablate or kill a PSMA-expressing
cell, e.g., a PSMA-expressing cancer or prostatic cell, either in vitro
or in vivo, are also provided.