The present application includes biomarkers, methods, devices, reagents,
systems, and kits for the detection and diagnosis of lung cancer. In one
aspect, the application provides biomarkers that can be used alone or in
various combinations to diagnose lung cancer or permit the differential
diagnosis of pulmonary nodules as benign or malignant. In another aspect,
methods are provided for diagnosing lung cancer in an individual, where
the methods include detecting, in a biological sample from an individual,
at least one biomarker value corresponding to at least one biomarker
selected from the group of biomarkers provided in Table 1, Col. 2,
wherein the individual is classified as having lung cancer, or the
likelihood of the individual having lung cancer is determined, based on
the at least one biomarker value.