Heating, ventilation, air conditioning, and refrigeration (HVAC&R) systems and heat exchangers are provided which include dissimilar tube spacing configurations. The heat exchangers include multiple sets of multichannel tubes in fluid communication with each other. One set of multichannel tubes contains a plurality of tubes spaced apart at one spacing while the another set of multichannel tubes contains a plurality of tubes spaced apart at a different spacing. The different spacing between the multichannel tubes allows each set of tubes to be configured to the properties of the refrigerant flowing within the tubes.