In accordance with various aspects of the present invention, system and method for modeling and application of interproximal reduction (IPR) of teeth to facilitate orthodontic treatment is provided. In accordance with an exemplary embodiment, a system and method for modeling and application of IPR are configured within a treatment methodology that initially determines whether stripping is needed for two neighboring teeth. If stripping is necessary, the exemplary method for modeling and application of IPR is conducted. In an exemplary embodiment, a stripping plane or other surface is constructed to determine the amount and region of stripping for two neighboring teeth, in other words, the volume to be removed between two neighboring teeth. After stripping of the tooth, the tooth geometry can be reconstructed to enable application of the IPR tooth model, such as enabling the clinician to utilize the IPR tooth model for teeth movement planning.