In one embodiment, a system and method for quantifying cardiac dyssynchrony relate to capturing images of the heart over time as it beats, generating heart function profiles for discrete portions of the myocardium from the captured images, the heart function profiles each pertaining to a heart function parameter as a function of time, and performing cross-correlation on the generated heart function profiles to yield a cross-correlation function that identifies a time delay at which the heart function profiles temporally correlate most closely, the time delay being indicative of a degree of cardiac dyssynchrony.