The invention provides pharmaceutical compositions comprising TGF-.beta. superfamily members and sugars, the compositions allowing improved recovery and/or increased biological activity of the TGF-.beta. superfamily member incorporated therein. The invention also relates to uses of sugars to improve the recovery or increase the biological activity of TGF-.beta. superfamily members in a pharmaceutical composition. Uses of the pharmaceutical compositions are also described, particularly with reference to wound healing and fibrosis. Furthermore, the invention discloses medicaments for the prevention or reduction of injection pain.