The invention describes improved methods and mechanisms for providing secure access to pharmaceutical and supply items in a clinical setting. In one version of the invention, a dispensing unit has an interior housing one or more drawers. Each drawer has one or more storage locations. The fronts of the drawers are covered with one or more locking doors, preventing access to a particular drawer, unless the covering door is unlocked. Indicators are mounted on the side of the enclosure, to guide the user to a drawer covered by an associated unlocked door. The unit further includes indicators on the sides of the drawers, to guide the user to the right storage receptacles or pockets within the drawer. Some pockets may have lids. Some of the lids may have locks. Sensors associated with at least some of the individual pocket lids may be provided to detect the lifting of a lid. Means to automatically detect the entry of a hand or fingers into a pocket may be provided. One or more loudspeakers may be mounted on the unit, to provide auditory guidance and confirmation of correct access, by sounds and voice prompts. One or more video cameras may be mounted on the unit. A processor is mounted in the unit, or, in the case of an auxiliary unit, the auxiliary unit is connected to the processor on the main unit. The processor is connected to receive signals from sensors in the dispensing unit, from the video camera, and to send signals to the indicators, and to send auditory information to loudspeakers which are designed to focus the sound specifically to the user. Modular locking drawers may be mounted in this unit also, dispensing individual doses using a method where the drawer has to be fully closed for each unit dose of medication taken.