A reduced pressure treatment system includes a first fluid pathway in communication with a reduced pressure source and a second fluid pathway. The system includes a reduced pressure manifold having a substantially gas impermeable barrier and at least one outer conduit defining a lateral edge of an interior region. The outer conduit and the substantially gas impermeable barrier enclose a portion of the interior region. The outer conduit is in fluid communication with one of the first and second fluid pathways. The outer conduit has at least one opening in fluid communication with the interior region. An inner conduit is at least partially disposed within the interior region and is in fluid communication with another of the first and second fluid pathways. The inner conduit has at least one opening in fluid communication with the interior region