Methods and systems for detecting the insertion, removal, and change of objects of interest through the use of imagery are disclosed. In one embodiment, a method includes performing a scene registration including aligning image patterns in the first image to those in the second image; performing a feature content analysis to determine a likelihood of change for each pixel in the first and second images; performing a region identification to group pixels within the first and second images into one or more image regions based upon their likelihood of change; and performing an image region partitioning to prioritize the one or more image regions according to an image region score for each of the one or more image regions, the image region score being indicative of at least one of insertion, removal, and change of an object of interest within the common area of interest. Embodiments of the invention may advantageously provide an autonomous capability to detect the insertion, removal, and change of objects of interest.