Pyrazole derivatives of the following formula (I), having affinity for the cannabinoidergic CB1 and/or CB2 receptors: ##STR00001## wherein: R is a group selected from C.sub.1-C.sub.10 alkyl; aryl, arylalkyl or arylalkenyl, not substituted or having from one to four substituents, equal to or different from each other; A is a group selected from the following: an ether group of formula --(CH.sub.2)--O--(CH.sub.2).sub.v--R'' wherein v is equal to 1 or 2; R'' is as defined in the present application; a ketone group of formula --C(O)--Z', wherein Z' is as defined in the present application; a substituent having an hydroxyl function of formula --CH(OH)--Z', being as defined in the present application; an amide substituent of formula --C(O)--NH-T', T' being as defined in the present application; B is a group as defined in the present application; D is an heteroaryl optionally substituted.