The present disclosure relates generally to systems and methods for combining stepped drain bias control with digital predistortion for a power amplifier. In one example, the method includes receiving an input associated with a transmit power level of a transmitter in a wireless terminal and selecting a predefined drain bias setting for a power amplifier of the wireless terminal based on the input. A predefined predistortion setting for the power amplifier corresponding to the selected predefined drain bias setting is identified. A drain of the power amplifier is set to the selected predefined drain bias setting, and the identified predefined predistortion setting is applied to a signal prior to directing the signal to the power amplifier.