A novel inbred maize variety designated PHE2E and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing inbred maize variety PHE2E with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PHE2E through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the inbred variety PHE2E or a trait conversion of PHE2E with another maize variety. Inbred maize varieties derived from inbred maize variety PHE2E, methods for producing other inbred maize varieties derived from inbred maize variety PHE2E and the inbred maize varieties and their parts derived by the use of those methods.