A multi-tapered endodontic file is provided, formed from shaft of material having a shaft. The shaft includes a working portion having one or more tissue-removing edges, points and/or surfaces. The working portion includes at least a first flute and a second flute. The first flute is tapered along its length in accordance with a first predetermined taper function. The second flute is tapered along its length in accordance with a second predetermined taper function.