A method of manufacturing a dental prosthesis to be implanted in a jaw of a patient, including the production of a radiological guide whose image, when the guide is placed in position on the jaw of the patient, can be processed for introducing virtual implants and guide cylinders in a surgically appropriate position; drilling holes into the guide on the basis of information obtained from the processing and placing real guide cylinders into the holes in order to form a surgical guide; placing the surgical guide on a pattern of the patient's jaw and drilling holes into the pattern through the guide cylinders; placing implant analogues into the holes drilled into the pattern; and producing the dental prosthesis on the pattern. Also, an appliance for carrying out the manufacturing method.