Problem: Providing a composition with an action of decreasing uric acid level in human sera from a residue from distillation of distilled spirits from barley as a material having been disposed so far despite no safety problem, by a simple treatment method suitable for practical industrial-scale production without any complex purification step. Means for Solving the Problem: A serum uric acid level-decreasing agent containing as the active ingredient a component from barley subjected to fermentation, preferably a residue from distillation of distilled spirits from barley, or a liquid fraction (residual solution from distillation of distilled spirits from barley) obtained by subjecting the residue from distillation of distilled spirits from barley to a separation procedure to a solid fraction and the liquid fraction, and/or a composition obtained by fractionating the residual solution from distillation of distilled spirits from barley, which is preferably a pharmaceutical agent for the prophylaxis or therapeutic treatment of diseases requiring the decrease of serum uric acid level. A composition containing the serum uric acid level-decreasing agent is in a form of foods and drinks, pharmaceutical products and quasi-pharmaceutical products, or feeds. Foods and drinks with a label telling that the foods and the drinks are used for the prophylaxis of diseases requiring the decrease of serum uric acid level, preferably functional foods and drinks, foods and drinks as nutritious supplements or healthy foods and drinks, for decreasing serum uric acid level.